Laboratory for Optical and Computational Instrumentation
Kevin Eliceiri is Director of the Laboratory for Optical and Computational Instrumentation (LOCI), and permanent principal investigator in the Laboratory for Cell and Molecular Biology (LCMB) in the Graduate School at UW–Madison. Eliceiri is also a member of the Departments of Biomedical Engineering and Medical Physics, the UW Carbone Cancer Center (UWCCC) and the McPherson Eye Research Institute. He is also an affiliate investigator of the Morgridge Institute for Research focusing on the development of Medical Devices. Eliceiri’s research focuses on biophotonics, the use of light to investigate biological phenomena and bio-image informatics, the application of computational techniques to analyze and process bioimages. He collaborates with investigators around the world on the development and application of optical and computational methods to study a range of biological processes including cancer progression and stem cell differentiation. A major emphasis of current research is the developing of advanced imaging methods for the improved detection and characterization of cancer invasion and progression.
Much of our knowledge of the biological world is the result of images collected with microscopes. For example, research scientists use them to understand the workings of a cell, the development of an organism or the pathological state of a tissue. Early biologists used simple lenses, and later, compound microscopes, to observe the natural world and record their observations as drawings. Over the last thirty years there have been significant advances in optical imaging and digital image processing with the introduction of many sophisticated instruments including confocal and multiphoton light microscopes. Using these techniques, biologists have the ability to monitor biological phenomena with unprecedented resolution. Modern imaging systems depend on many different engineering approaches, whose details are largely anonymous to the biologist. Some examples include the electronics for data capture, the lasers for image illumination, the optics for specimen interrogation, and the signaling, processing and software approaches for data acquisition, analysis and visualization. “The Engineered Image” will explore the diverse and significant contributions of the UW Engineering community, and related collaborators, to recent improvements in modern microscopy.
Approximate Length of Talk: 45 minutes to 1 hour
- Visualization of Cancer Invasion and Progression
- Biophotonics: Convergence of Light and Biomedical Application
- Seeing is Believing: the Cellular World
- Cells and Cancer
- Visualizing Multidimensional Biological Processes